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Materials News
Label varnishing comes under scrutiny
W
hile analysing stability data of a particularly potent drug stored inside an HDPE bottle, a US scientist discovered that a molecule of a benzophenone, a compound used in the varnish coating of a bottle's label had travelled on its own - through the label and the bottle - before coming to rest on a tablet inside.The pharmaceutical industry has long been aware of the ability of some molecules to migrate. And this particular molecule was not toxic at the levels seen in the stability data; benzophenone has been detected in European food products, including cereals. Still, the scientist says this research has implications for the pharmaceutical industry. If benzophenone is readily migrating onto drugs but going undetected because routine monitoring doesn't catch it, what does that mean for patients?
The scientist says that at the least, this research could impact one's choice of label varnish, especially in potent products.
These findings were presented at a recent American Association of Pharmaceutical Scientists annual conference.